Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
Onset: Oral (conventional tablet): 1 hr.
Duration: Oral (conventional tablet): 3-6 hr.
Absorption: Readily absorbed from the GI tract (oral).
Distribution: Widely distributed. Crosses the placenta and enters breast milk.
Metabolism: Extensive hepatic first-pass metabolism; converted to O-desmethyltramadol (active) by N- and O-demethylation via the cytochrome P450 isoenzymes CYP3A4 and CYP2D6 and glucuronidation or sulfation.
Excretion: Via urine (as metabolites); 6 hr (elimination half-life).
Onset: Oral (conventional tablet): 1 hr.
Duration: Oral (conventional tablet): 3-6 hr.
Absorption: Readily absorbed from the GI tract (oral).
Distribution: Widely distributed. Crosses the placenta and enters breast milk.
Metabolism: Extensive hepatic first-pass metabolism; converted to O-desmethyltramadol (active) by N- and O-demethylation via the cytochrome P450 isoenzymes CYP3A4 and CYP2D6 and glucuronidation or sulfation.
Excretion: Via urine (as metabolites); 6 hr (elimination half-life).
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