Dosage

Oral
moderate to severe pain
Adult: As conventional tablet: 50-100 mg every 4-6 hr. Max: 400 mg daily. As extended-release tablet: 50-100 mg once or twice daily. Max: 300 mg daily.
Elderly: Lower initial dose. Max: 300 mg daily (>75 yr).
Max Dosage: 400 mg daily.

CrCl (ml/min)	Dosage Recommendation
10-<30	As conventional tablet: increase dosage interval to 12 hr; max: 200 mg/day.
<10	Contraindicated.

Hepatic impairment: As conventional tablet: Increase dosage interval to 12 hr in severe impairment e.g. 50 mg bid in hepatic cirrhosis. As extended-release tablet: Contraindicated in Child Pugh Class C.
Parenteral
moderate to severe pain
Adult: IM/IV inj over 2-3 min/IV infusion: 50-100 mg given every 4-6 hr.
Elderly: Lower initial dose. Max: 300 mg daily (>75 yr).

CrCl (ml/min)	Dosage Recommendation
10-<30	Increase dosage interval to 12 hr.
<10	Contraindicated.

Hepatic impairment: Severe: Increase dosage interval to 12 hr.
Parenteral
Postoperative pain
Adult: IM/IV inj over 2-3 min/IV infusion: Initially, 100 mg followed by 50 mg every 10-20 min if necessary up to 250 mg for the 1st hr. Maintenance: 50-100 mg every 4-6 hr. Max: 600 mg daily.
Elderly: Lower initial dose. Max: 300 mg daily (>75 yr).

CrCl (ml/min)	Dosage Recommendation
10-<30	Increase dosage interval to 12 hr.
<10	Contraindicated.

Hepatic impairment: Severe: increase dosage interval to 12 hr.
Rectal
moderate to severe pain
Adult: 100 mg suppository up to 4 times daily.
Elderly: Lower initial dose. Max: 300 mg daily (>75 yr).

CrCl (ml/min)	Dosage Recommendation
<30	Increase dosage interval to 12 hr.
<10	Contraindicated.

Hepatic impairment: Severe: Increase dosage interval to 12 hr.

Incompatibility: Incompatible with injections of diazepam, diclofenac sodium, indometacin, midazolam, piroxicam, phenylbutazone, aciclovir, clindamycin and lysine aspirin if mixed in the same syringe.